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KMID : 1151920210030010008
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Chronobiology in Medicine
2021 Volume.3 No. 1 p.8 ~ p.15
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Understanding Skin Chronobiology to Unveil and Transform Dermal Chronotherapeutics: Paving the Way for the Future
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Thoke Jagruti
Patel Shivangi
Majumdar Anuradha
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Abstract
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All the organisms on earth spontaneously tend to exhibit certain inherent tendency that helps them to adapt to their respective environment, which is monitored by internal biological clock. The basic rudiments of skin circadian rhythm which varies with diurnal-nocturnal pattern as well as the seasonal pattern is explained. Correlation between sleep and dermatological ailment like psoriasis, eczema, and aging is described. The recent application of chronopharmacological studies in age prediction, wound healing, and fat metabolism is summarized. The diverse circadian activity of skin tends to affect pharmacodynamics and pharmacokinetics of drug providing a temporal link to drug and its effects.
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KEYWORD
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Circadian rhythm, Pharmacodynamics, Pharmacokinetics, Seasonal affective disorders, Wound healing
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